Understanding non-canonical phosphatidylinositol kinases as vulnerabilities in prostate cancer metabolism (Dr. Joanna Triscott, Senior Postdoctoral Scientist)
Phosphatidylinositol regulating enzymes have a high frequency of alteration in advanced prostate cancer. In this project we are the first to investigate PI5P4K in prostate biology. This lipid kinases family is implicated in cell stress and cancer metabolism, as well, may have a signaling interplay with key drivers of cancer progression. We have developed novel animal models, queried metabolism pathways in vitro, and implemented multi-omic tools to characterize the impact of PI5P4K depletion in prostate cells. Our long-term goal is to untangle the role for PI5P4K in the context of prostate cancer in order to establish the rationale for developing PI5P4K inhibitors for clinical application.
This project has been funded by the Swiss National Research Foundation, the Marie Skłodowska-Curie Actions (MSCA), and the Johanna Dürmüller Bol foundation.
